Inertia

I’ve discovered that once I get to a point where something is completed (e.g., a chapter), I have real trouble getting myself to start the next part. At first it’s like, “oh, I’ll just take a little break and watch this movie/check out this website/whatever”… and then it’s like “oh, before I start the next thing, I should really do some laundry/vacuum/pay the bills/update my thesis blog/etc.”… and the next thing I know it’s three days later and I haven’t done a stitch of work. I wonder what that says about me….

Chapter 3 Draft Done!

A draft of chapter 3 is now done and ready for my supervisor to read (and, most likely, rip to shreds). It’s good timing, because the new Harry Potter book comes out today, so I can enjoy reading it knowing that I’ve finished that. Granted, I was expecting to have my entire lit review done by this point, but you can’t have everything in life, now can you?

Coolest.Feature.Ever

So I’m reading an article online today (which, in itself is already super cool — I almost never need to actually go to a library anymore! I can sit at my computer all day without ever moving a muscle or burning a calorie! And we wonder why we have an obesity epidemic going on… but I digress). So I’m reading the article and I click on one of the figures to have a closer look and I see a button that says “PowerPoint slide for teaching.” So, of course, I’ve gotta click on that to check it out — apparently this journal prepares the figures from the articles as PowerPoint slides, complete with citation and the journal’s logo… I may never have to do any work of my own again!

Fun with Spell Check

Apparently the word “neuropilin” isn’t in Microsoft’s dictionary. Which is fine — it’s a scientific word that isn’t common in every day usage (in case you are interested, it’s a protein involved in blood vessel and nerve cell development). But when spell check gave it’s suggestion of what word I might be looking for, it suggested necrophilia. Oh spell check, you have such a dirty mind!

Time Management

It was 9:30 p.m. before I actually sat down to work on my thesis today (well, I guess technically that was yesterday). Who knew that it was possible to procrastinate that long?

Thesis Outline

Thesis Outline

Chapter 1: Literature Review

1. Fetal Programming/Fetal Origins of Adult Disease
2. Fetal Alcohol Syndrome
3. Growth Retardation
   1. Symmetrical vs. Asymmetrical
   2. Causes (Ethanol, Malnutrition, Genetic Disorders, other teratogens (smoking, caffeine??)) – compare & contrast

4. Fetal Bone Development
   1. Endochondral vs. Intramembranous
   2. Stages of Endochondral Bone Development
   3. Factors Regulating Endochondral Bone Development

5. Calcium Regulation
   1. normal
   2. during pregnancy
   3. fetal

6. Animal Models
   1. Animal Models of Fetal Alcohol Syndrome
      1. pros & cons of different methods of E administration
      2. comparing animal models to humans (BAC issue; trimester issue?)

   2. Animal Models of Fetal Bone Development
   1. pros & cons of different species

7. Thesis Objectives

Chapter 2: Dose Response Paper

Chapter 3: Histology Paper

Chapter 4: Discussion

1. Discussion and conclusions relating manuscript chapters to each other and to the discipline or field of study
2. Strengths/limitations
3. Future Directions
   1. Elucidating Mechanisms (immunohistochemistry; DNA microarry, intramembranous ossification, calcium supplementation/deficiency)
   2. Biomarker for alcohol exposure for diagnosis of ARND (how specific is the bone effect? how sensitive?)
   3. Fetal programming (potential for long term effects)
   4. Bone fracture repair?
   5. Calcification of the artery during atherosclerosis recapitulates endochondral ossification – would ethanol affect it?

Appendices

1. figures not included in Dose Response Paper
2. figures not included in Histology Paper (if any)
3. Animal Care certificates

Progress So Far

Since I’m starting this blog after starting the actual thesis writing, I should probably give some background. I’m working on a Ph.D. in Human Nutrition at The University of British Columbia in Vancouver, British Columbia, Canada.

My thesis will consist of four chapters:

1. Literature Review – outline drafted (on a beach in Santa Barbara), awaiting supervisor’s feedback
2. Dose Response Study – already completed
3. Histology Study – 3/4 of 1st draft written
4. Discussion – outline drafted (on a beach in Santa Barbara), awaiting supervisor’s feedback

OK, now you are up-to-speed. Lucky you. I better get back to work on the discussion for chapter 3. Yeesh.